Bergerot, I, et al. Effects of insulin like growth factor-1 and insulin on effector T cells generating autoimmune diabetes. Diabetes & Metabolism 22(4):235-239 (1996). The development of autoimmune diabetes in experimental mice was significantly reduced in those receiving IGF-1 as compared to insulin.
Bhora F, Dunkin B, Batzri S, et al. (1995) Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgery Res. 59:236-244.
Bhora, Y, et al. Effect of growth factors on cell proliferation and epithelialization in human skin. Journal of Surgical Research 59(2):236-244 (1995). Fibroblast growth factor (FGF), IGF-1 and epithelial growth factor (EGF) are important factors in healing skin wounds. EGF in particular is capable of initiating epithelial growth.
Burrin D, Davis T, Ebner S, Schoknecht P, Fiorotto M, Reeds P. (1997) Colostrum enhances the nutritional stimulation of vital organ protein synthesis in neonatal pigs. American Society for Nutritional Sciences.127(7):1284-9.
Burrin DG, Shulman RJ, Reeds PJ, Davis TA, Gravitt KR. (1992) Porcine colostrum and milk stimulate visceral organ and skeletal muscle protein synthesis in neonatal piglets. Journal of Nutrition. 122:1205-1213.
Cass TL. Insulin-like growth factor-1 (IGF-1, Somatomedin C) blood levels are not associated with prostate specific antigen (PSA) levels or prostate cancer: A study of 749 patients. Medical College of Wisconsin, Milwaukee, WI.
Donovan, SM, Hartke, JL, Monaco, MH, Wheeler, MB. (2004) Insulin-like Growth Factor-I and Piglet Intestinal Development. Journal of Dairy Science 87(E Suppl.):E46-54. Piglets suckling from IGF-1 transgenic sows (i.e. sows that have been transgenically altered to overexpress IGF-1 in their milk) showed increased villus growth and disaccharidase activity, indicating improved intestinal health.
Francis G, Read L, Ballard J, et al. (1986) Purification and partial sequence analysis of insulin-like growth factor-1 from bovine colostrum. Journal of Biochemistry. 233:207-213.
Francis G, Upton F, Ballard J, McNeil K, Wallace J. (1988) Insulin-like growth factors 1 and 2 in bovine colostrum. Journal of Biochemistry. 251:95-103.
Ginjala V, Pakkanen R. (1998) Determination of transforming growth factor-B1 (TGF-B1) and insulin-like growth factor 1 (IGF-1) in bovine colostrum samples. Journal of Immunoassay. 19:195-207.
Handsell KL, Baumrucker CR, Kensinger RS. (1993) Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase. Journal of Endocrinology. 137:223-230.
Marcotty C, Frankenne F, Van Beeumen J, Maghuin-Rogister G, Hennen G. (1991). Insulin-like growth I (IGF-I) from cow colostrum: Purification and characterization. Growth Regulation. 1(2):56-61.
Noda K, Umeda M, Ono T. (1984) Transforming growth factor activity in human colostrum. Gann. 75:109-12.
Oz, HS, Ray, M, Chen, TS, McClain, CJ. (2004) Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease. Journal of the American College of Nutrition 23(3):220-6. Mice with an experimentally-induced inflammatory bowel disease fed a diet rich in transforming growth factor beta-2 (TGF-ß2) gained more weight, did not develop diarrhea or prolapse, had lower pathological scores and lower serum amyloid (SAA). This study supports the use of TGF-ß2 diets in the treatment of Crohn’s disease.
Pakkanen R, Aalto J. (1997) Review paper: Growth factors and antimicrobial factors of bovine colostrum. International Dairy Journal. 7:285-297.
Pakkanen R. (1998) Determination of transforming growth factor-fl2 (TGF-fl2) in bovine colostrum samples. Journal of Immunoassay. 19:23-37.
Tokuyama H, Tokuyama Y, Migita S. (1990) Isolation of two new proteins from bovine colostrum which stimulates epidermal growth factor-dependent colony formation of NRK-49F cells. Growth Factors. 3(2): 105-14.
Tokuyama, H. and Tokuyama, Y. (1989) Bovine colostric transforming growth facto-fI-like peptide that induces growth inhibition and changes in morphology of human osteogenic sarcoma cells (MG-63). Cell Biology International Reports. 13:251-258.
Tokuyama Y. (1993) Purification and identification of TGF-B2-related growth factor from bovine colostrum. Journal of Dairy Research. 60:99-109.
Tollefsen S, Lajara R, McCusker R, Clemmons D, Rotwein P. (1989) Insulin-like growth factors (IGF) in muscle development. Journal of Biological Chemistry. 264(23):13810-7.
Tomas F, Knowles S, Owens P, et al. (1991) Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I. Biochem J. 276 (Pt 2):547-54.
Ullman M, Ullman A, Sommerland H, Skottner A, Oldfors A. (1990) Effects of growth hormone on muscle regeneration and IGF-I concentration in old rats. Acta Physiological Scand. 140:521-525.
Watson DL, Francis GL, Ballard FJ. (1992) Factors in ruminant colostrum that influence cell growth and murine IgE antibody responses. Journal of Dairy Research. 59:369-380.
Tavakkol, A, et al. Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. Journal of Investigative Dermatology 99(3):343-349 (1992). Receptors for growth hormone and IGF-1 were isolated from human skin, indicating that skin cells may have the ability to react directly to growth hormone stimulation.
For Additional Links: www.scholar.google.com keywords: Colostrum, Growth Factors