Crook, TH, et al. Effects of phosphatidylserine in age-associated memory impairment. Neurology 41(5):644-649 (1991). Patients with age-associated memory impairment showed significant improvement in memory performance tests with phosphatidylserine supplementation over a 12 week period.
Crook, T, et al. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacology Bulletin 28(1):61-66 (1992). Another study which showed an improvement in symptoms of Alzheimer's with phosphatidylserine supplementation over 12 weeks. The less the impairment, the greater the improvement, suggesting that the earlier phosphatidylserine supplementation is begun in the course of the disease, the better the results will be.
Cross, CE, et al. Oxygen radicals and human disease. Annals of Internal Medicine 107(4):526-545 (1987). Oxygen free radicals, the by-products of normal metabolism, have been implicated in disease processes ranging from carcinogenesis to aging, emphasizing the importance of antioxidants in combating these conditions.
Leszek, J, et al. Colostrinin: proline-rich polypeptide complex from ovine colostrum - a long-term study of its efficacy in Alzheimer's disease. Medical Science Monitor 8(10):P193-P196 (2002). In a longer-term study, colostrinin produced improvement or stabilization in patients involved in the study.
Leszek, J, Inglot, AD, Janusz, M, Lisowski, J, Krukowska, K, Georgiades, JA. Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study. Archivum immunologiae et therapiae experimentalis (Warszava) 47(6):377-385 (1999).
Leszek, J, Inglot, AD, Janusz, M, Byczkiewicz, F, Kiejna, A, Georgiades, J, Lisowski, J. Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in Alzheimer's disease. Medical Science Monitor 8(10):193-196 (2002).
Mikulska, JE, Lisowski, J. A proline-rich polypeptide complex (PRP) from ovine colostrum. Studies on the effect of PRP on nitric oxide (NO) production induced by LPS in THP-1 cells. Immunopharmacology and Immunotoxicology 25(4):645-654 (2003).
Popik, P, Bobula, B, Janusz, M, Lisowski, J, Vetulani, J. Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats. Pharmacology and Biochemistry of Behavior 64(1):183-189 (1999).
Popik, P, Galoch, Z, Janusz, M, Lisowski, J, Vetulani, J. Cognitive effects of Colostral-Val nonapeptide in aged rats. Behavioral Brain Research 118(2):201-208 (2001).
Stewart, MG, Banks, D. Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm. Neurobiology of Learning and Memory prepublication (2006).
Schuster, D, Rajendran, A, Hui, SW, Nicotera, T, Srikrishnan, T, Kruzel, ML. Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of beta-amyloid. Neuropeptides 39(4):419-426 (2005).
Zablocka, A, Janusz, M, Macala, J, Lisowski, J. A proline-rich polypeptide complex and its nonapeptide fragment inhibit nitric oxide production induced in mice. Regulatory Peptides 125(1-3):35-39 (2005).
For Additional Links: www.scholar.google.com keywords: Colostrum, Alzheimer's