Bilikiewicz, A, Gaus, W. Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease. Journal of Alzheimer’s Disease 6(1):17-26 (2004).
Leszek, J, et al. Colostrinin: proline-rich polypeptide complex from ovine colostrum - a long-term study of its efficacy in Alzheimer's disease. Medical Science Monitor 8(10):P193-P196 (2002). In a longer-term study, colostrinin produced improvement or stabilization in patients involved in the study.
Leszek, J, Inglot, AD, Janusz, M, Lisowski, J, Krukowska, K, Georgiades, JA. Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of Alzheimer's disease. A double-blind, placebo-controlled study. Archivum immunologiae et therapiae experimentalis (Warszava) 47(6):377-385 (1999).
Leszek, J, Inglot, AD, Janusz, M, Byczkiewicz, F, Kiejna, A, Georgiades, J, Lisowski, J. Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in Alzheimer's disease. Medical Science Monitor 8(10):193-196 (2002).
Mikulska, JE, Lisowski, J. A proline-rich polypeptide complex (PRP) from ovine colostrum. Studies on the effect of PRP on nitric oxide (NO) production induced by LPS in THP-1 cells. Immunopharmacology and Immunotoxicology 25(4):645-654 (2003).
Popik, P, Bobula, B, Janusz, M, Lisowski, J, Vetulani, J. Colostrinin, a polypeptide isolated from early milk, facilitates learning and memory in rats. Pharmacology and Biochemistry of Behavior 64(1):183-189 (1999).
Popik, P, Galoch, Z, Janusz, M, Lisowski, J, Vetulani, J. Cognitive effects of Colostral-Val nonapeptide in aged rats. Behavioral Brain Research 118(2):201-208 (2001).
Stewart, MG, Banks, D. Enhancement of long-term memory retention by Colostrinin in one-day-old chicks trained on a weak passive avoidance learning paradigm. Neurobiology of Learning and Memory prepublication (2006).
Schuster, D, Rajendran, A, Hui, SW, Nicotera, T, Srikrishnan, T, Kruzel, ML. Protective effect of colostrinin on neuroblastoma cell survival is due to reduced aggregation of beta-amyloid. Neuropeptides 39(4):419-426 (2005).
Zablocka, A, Janusz, M, Macala, J, Lisowski, J. A proline-rich polypeptide complex and its nonapeptide fragment inhibit nitric oxide production induced in mice. Regulatory Peptides 125(1-3):35-39 (2005).
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